About CALM-Brain

Changes in the structure and function of the brain that result in disorders are poorly understood. Neither do we understand why some individuals are more prone to developing brain disorders than others. Understanding these underlying changes in the brain will likely lead to better methods to diagnose and treat mental illness.

The CALM (CBM ADBS Longitudinal Multimodal) Brain Data Resource provides the scientific community with freely neuroimaging datasets collected from clinically dense families via the CBM-ADBS study to pursue questions along this line. The neuroimaging datasets are complemented with genetic and clinical data collected from the same cohort. By compiling and distributing this, we hope to facilitate a better understanding of brain disorders.

CALM-Brain is hosted by gin.ncbs.res.in and an SQL instance. It provides the community with access to most neuroimaging, genetic, and clinical data collected by the CBM-ADBS study. All data is available via calm-brain.ncbs.res.in

Data Use Agreement

CALM-Brain is distributed to the greater scientific community by the CBM-ADBS study under the following terms:

1. You agree not to attempt to establish the identity of or to make contact with any of the included human participants. This prohibition includes, but is not limited to, the use of facial recognition and 3D facial rendering technologies.
2. You agree to acknowledge the use of the CALM-Brain resource and any data derived from it in all public presentations of results or algorithms that benefited from their use. This includes:
   1. Acknowledgments: "Data was provided [in part] by CALM-Brain [insert appropriate release version]. Data in the CALM-Brain resouce was collected by CBM-ADBS study.”
   2. Citation: Until a journal article is available for the resource, please cite the below reference.
      • Viswanath, B., Rao, N.P., Narayanaswamy, J.C. et al. Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science. BMC Psychiatry 18, 106 (2018). doi: https://doi.org/10.1186/s12888-018-1674-2.
3. You agree to provide the Center for Brain and Mind with information about your use of the CALM-Brain resource upon request.
4. You acknowledge that failure to comply with these data use terms may result in the termination of your right to access and use the CALM-Brain resource.

Who Can Obtain Access?

Anyone with a scientific usecase can request for access. The resource is divided into different zones and the access request should mention the zones of interest. Lower zones have a strict vetting process and require a detailed statement.

• Zone 1: Contains raw data collected. Access requests to this is not possible.
• Zone 2: Contains pre-release data. Comes with compute resources to perform local analysis via access to the server that hosts the data.
• Zone 3: Contains anonymized and stable release.
• Zone 4: Contains the resource index and is openly accessible. You can try it out here.

By submitting the data request you agree to abide by the terms of this Data Use Agreement.

Apply for access

Releases

• Pre-release 1.0

Publications

Discovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science

Viswanath B, Rao N P, Narayanaswamy J C et al. BMC Psychiatry, 18, 106, 2018. doi: 10.1186/s12888-018-1674-2

Citing

We request authors of publications or presentations using the CALM-Brain resource to cite the publication that describes the methods used to acquire and process the data.

All CALM-Brain data use requires acceptance of the Data Use Agreement. To download a index, click on the release of interest.

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